Full Publication List on Google Scholar

Full Publication List on Pubmed


J Guo, H Jiang, K Oguntuyo, B Rios, Z Boodram, N Huebsch. Interplay of Genotype and Substrate Stiffness in driving the Hypertrophic Cardiomyopathy Phenotype in iPSC-Micro-Heart Muscle Arrays. Cellular and Molecular Bioengineering. 2021. Young Innovators Special Issue. doi: https://doi.org/10.1007/s12195-012-00684-x.

FT Lee-Montiel, A Laemmle, L Dumont, CS Lee, N Huebsch, V Charwat, H Okochi, MJ Hancock, B Siemons, S Boggess, I Goswami, E Miller, H Willenbring, KE Healy. Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interactions. Frontiers in Pharmacology. 2021; 12: 977. doi: 10.3389/fphar.2021.667010

E Jain, S Neal, H Graf, X Tan, R Balasubramaniam, N Huebsch. Copper-Free Azide–Alkyne Cycloaddition for Peptide Modification of Alginate Hydrogels. ACS Applied Bio Materials. 2021. doi: 10.1021/acsabm.0c00976


J Guo, DW Simmons, G Ramahdita, MK Munsell, K Oguntuyo, B Kandalaft, B Rios, M Pear, D Schuftan, H Jiang, SP Lake, GM Genin, N Huebsch. Substrate Grafted iPSC-Derived Micro Heart Muscles to Investigate Effects of Mechanical Loading on Cardiac Physiology. ACS Biomaterials Science & Engineering. 2020. doi: 10.1021/acsbiomaterials.0c00318

J Guo, N Huebsch. Modeling the Response of Heart Muscle to Mechanical Stimulation in vitro. Current Tissue Microenvironment Reports. 2020. doi: 10.1007/s43152-020-00007-8


N Huebsch. Translational Mechanobiology: Designing Synthetic Hydrogel Matrices for Improved In Vitro Models and Cell-Based Therapies. Acta Biomaterialia. 2019; 94: 97-111. doi: 10.1016/j.actbio.2019.05.055

P Loskill, N Huebsch. Engineering Tissues from Induced Pluripotent Stem Cells. Tissue Eng. A. 2019. 25(9-10): 707-10. doi: 10.1089/ten.tea.2019.0118


N Huebsch*, B Charrez*, B Siemons, SC Boggess, S Wall, V Charwat, KH Jæger, FT Lee-Montiel, N Jeffreys, N Deveshwar, A Edwards, J Serrano, M Snuderl, A Stahl, A Tveito, EW Miller, KE Healy. Metabollically-Driven Maturation of Human Induced Pluripotent Stem Cell Derived Heart-On-A-Chip. BioRxiv 485169. doi: https://doi.org/10.1101/485169 *Equal first authors.           

SC Boggess, SS Gandhi, BA Siemons, N Huebsch, KE Healy, EW Miller. New Molecular Scaffolds for Fluorescent Voltage Indicators. ACS Chem Biol. 2019; 14(3): 390-6. doi: 10.1021/acschembio.8b00978

A Tveito, KH Jæger, N Huebsch, B Charrez, AG Edwards, S Wall, KE Healy. Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems. Sci Rep 2018; 8(1): 17626. doi: 10.1038/s41598-018-35858-7

Z Ma*, N Huebsch*, S Koo*, MA Mandegar, B Siemons, BR Conklin, CP Grigoropolous, KE Healy.  Synergy of MYBPC3 Deficiency and Mechanical Overload Leads to Contractile Deficits in Engineered Cardiac Tissue. Nat Biomed. Eng. 2018; 2(12): 955-67. doi: 10.1038/s41551-018-0280-4  * Equal first authors.

P Hoang, N Huebsch, SH Bang, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S. Quantitatively Characterizing Drug-Induced Arrhythmic Contractile Motions of Human Stem Cell-Derived Cardiomyocytes. Biotechnol. Bioeng. 2018; 115(8): 1958-70. doi: 10.1002/bit.26709 


LM Judge, JA Perez-Bermejo, A Truoung, AJ Ribeiro, JC Yoo, CL Jensen, MA Mandegar, N Huebsch, RM Kaake, PL So, D Srivastava, BL Pruitt, NJ Krogan, BR Conklin. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. JCI Insight. 2017; 2(14). Pii: 94623. doi: 10.1172/jci.insight.94623

A Cipitria, K Both, S Schoenhals, DS Garske, K Schmidt-Bleek, A Ellinghaus, A Dienelt, A Peters, M Mehta, CM Madl, N Huebsch, DJ Mooney, GN Duda. In-situ tissue regeneration through SDF-1a driven cell recruitment and stiffness-mediated cell differentiation in a rat femoral critical-sized defect. Acta Biomater. 2017; pii: S1742-7061(17)30470-1. doi: 10.1016/j.actbio.2017.07.032


N Huebsch, P Loskill, N Deveshwar, CI Spencer, LM Judge, MA Mandegar, C Fox, TMA Mohammed, Z Ma, A Mathur, AM Sheehan, M Saxton, J Yoo, D Srivastava, TA Desai, P So, KE Healy, BR Conklin Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses. Sci. Rep. 2016; 6: 24726. doi: 10.1038/srep24726

MA Mandegar, N Huebsch, EB Frolov, E Shin, LM Judge, Y Miyaoka, A Truong, AH Chan, CI Spencer, P So, Qi LS, Conklin BR. CRISPR Interference Efficiently Induces Gene Knockdown and Models Disease in iPSCs. Cell Stem Cell. 2016; 18(4): 541-53. doi: 10.1016/j.stem.2016.01.022

O Chaudhuri, L Guo, D Klumpers, M Darnell, S Bencherif, J Weaver, N Huebsch, HP Lee, E Lippens, GN Duda, DJ Mooney. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat. Mater 2016; 15(3): 326-34. doi: 10.1038/nmat4489


N Huebsch, E Lippens, K Lee, ST Koshy, MC Darnell, R Desai, M Mehta, CM Madl, M Xu, O Chaudhuri, X Zhao, KA Alim, A Mammato, DE Ingber, GN Duda, DJ Mooney. Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation. Nat Mater 2015; 14(12): 1269-77. doi: 10.1038/nmat4407

Z Ma, J Wang, P Loksill, N Huebsch, S Koo, FL Svedlund, NC Marks, MA Finnegan, CP Grigoropoulos, BR Conklin, KE Healy. Self-organizing cardiac microchamber mediated by geometric confinement. Nat Commun. 2015; 6: 7413. doi: 10.1038/ncomms8413

A Mathur, P Loskill, K Shao, N Huebsch, S Hong, SG Marcus, N Marks, M Mandegar, BR Conklin, LP Lee, KE Healy. Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications. Sci. Rep. 2015; 5: 8883. doi: 10.1038/srep08883

N Huebsch*, P Loskill*, MA Mandegar, NC Marks, AS Sheehan, Z Ma, AA Mathur, TN. Nguyen, JC Yoo, LM Judge, CI Spencer, AC Chukka, CR Russell,  PL So, BR Conklin, KE Healy. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales. Tissue Eng Part C Methods 2015; 21(5): 467-79. doi: 10.1089/ten.TEC.2014.0283 *Equal first authors.


N Huebsch*, C Kearney*, X Zhao*, J Kim, C Cezar, Z Suo, DJ Mooney. Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy. Proc. Natl. Acad Sci. USA, 2014; 111(27): 9762-7. doi: 10.1073/pnas.1405469111 * Equal first authors.

JD Boerckel, BA Uhrig, NJ Willett, N Huebsch, RE Guldberg. Mechanical Regulaton of Vascular Growth and Tissue Regeneration In Vivo. Proc. Natl. Acad. Sci. USA. 2011; 108(37): E674-80. doi: 10.1073/pnas.1107019108

YM Kolambkar, JD Boerckel, KM Dupont, M Bajin, N Huebsch, DJ Mooney, DW Hutmacher, RE Guldberg. Spatiotemporal delivery of bone morphogenic protein enhances functional repair of segmental bone defects. Bone 2011; 49(3): 485-92. doi: 10.1016/j.bone.2011.05.010

X Zhao, J Kim, C Cezar, N Huebsch, K Bouhadir, DJ Mooney. Active Scaffolds for On-Demand Drug and Cell Delivery. Proc Natl Acad Sci USA 2011; 108(1): 67-72. doi: 10.1073/pnas.1007862108

N Huebsch, PR Arany, AS Mao, D Shvartsman, OA Ali, SA Bencherif, J Rivera-Feliciano, DJ Mooney. Harnessing Traction-Mediated Manipulation of the Cell-Matrix Interface to Control Stem Cell Fate. Nat Mater. 9(6): 518-26. doi: 10.1038/nmat2732

N Huebsch, DJ Mooney. Inspiration and application in the evolution of biomaterials. Nature 2009; 462 (Insight Supplement): 1-7. doi: 10.1038/nature08601

OA Ali, N Huebsch, L Cao, G Dranoff, DJ Mooney. Infection-mimicking materials to program dendritic cells in situ. Nat Mater 2009; 8(2): 151-8. doi: 10.1038/nmat2357