Our lab focuses on fundamentally understanding how mechanical cues originating at cell-cell and cell-extracellular matrix contacts influence signaling and fate. We are especially interested in how those cues affect heart development and disease, and how we can leverage these cues to engineer 3D models of human tissue for disease modeling and drug discovery, and to design new biomaterials for tissue regeneration.
In our work, we use tools from stem cell engineering, image processing, molecular biology, chemistry and materials science. Our current projects include:
- Pluripotent-stem cell derived cardiac micro-tissues for modeling cardiac development, drug toxicity and cardiomyopathy
- Synthetic Extracellular Matrix Mimetics with defined presentation of adhesion ligands and growth factors
We welcome you to learn more about our research and our team.